About Fabry
> Effects & Progression Fabry disease symptoms can occur across the whole body.

Alex, an actual Fabry patient.

Fabry disease symptoms can occur across the whole body.

Fabry disease can affect many parts of the body, including the kidneys, heart, nervous system, skin, eyes, and more. The effects of Fabry are highly variable.

How Fabry Affects the Kidneys

Kidneys

  • Protein in the urine
  • Decreased kidney function
  • Kidney failure
How Fabry Affects the Heart

Heart

  • Irregular heartbeat (fast or slow)
  • Heart attack or heart failure
  • Enlarged heart
How Fabry Affects the Brain

Brain

  • Transient ischemic attack (TIA)
  • Stroke
How Fabry Affects the Nervous System

Nervous System

  • Nerve pain
  • Intolerance to heat, cold, or exercise
  • Burning in the hands and feet
  • Vertigo/feeling dizzy
How Fabry Affects the Skin

Skin

  • Sweating less than normal or not at all
  • Small, dark, red spots, mostly appearing between the belly button and upper thighs
How Fabry Affects the Eyes

Eyes

  • A whorled pattern in the cornea
  • Fabry cataracts
How Fabry Affects the Ears

Ears

  • Hearing loss, ringing in the ears (tinnitus)
How Fabry Affects the GI Tract

Gastrointestinal (GI)

  • Nausea, vomiting, cramping, and diarrhea
  • Pain/bloating after eating, feeling full after a small amount of food
  • Constipation
How Fabry Affects the Body

Psychological

  • Feelings of guilt, worry, depression, isolation, and/or fear
How Fabry Affects the Lungs

Lungs

  • Wheezing
  • Difficulty breathing, shortness of breath
  • Bronchitis
  • Chronic cough
Other Effects of Fabry

Others

  • Fatigue—a deep feeling of tiredness

“As a kid, I can remember getting cold rags in the middle of the night, or going into a cool bath, because my feet were burning, and my hands were burning so bad.” - Rebecca, on her symptoms of Fabry disease. Remember, symptoms may not be the same for everyone.
Watch her full story >

Watch Rebecca’s full story Rebecca Patient Ambassador | Golf

Because Fabry disease has a wide range of symptoms in many parts of the body, every person’s experience with Fabry may be unique. It can cause many types of health issues that may get worse at different rates in different people and may ultimately affect lifespan. For this reason, many different healthcare providers may be involved in treating and monitoring people with Fabry disease.

Understanding Fabry Progression

See how the effects of Fabry can get worse over time, from cells, to organs, and to you.

Do you know how Fabry disease is inherited?

Fabry is a genetic disease that can be passed down between generations.

Learn how

IMPORTANT SAFETY INFORMATION AND INDICATION

Before taking Galafold® (migalastat), tell your healthcare provider about all of your medical conditions, including if you:

  • have kidney problems.
  • are pregnant or plan to become pregnant. It is not known if Galafold will harm your unborn baby.
  • have kidney problems.
  • are pregnant or plan to become pregnant. It is not known if Galafold will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. Galafold may pass into breast milk. Talk to your healthcare provider
    about the best way to feed your baby if you take Galafold.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take medicines or supplements containing caffeine as these medicines or supplements may affect how Galafold works.

How should I take Galafold?

Do not eat food, or take or drink any product that contains caffeine at least 2 hours before and 2 hours after taking Galafold to give a minimum 4 hour fast.

What are the possible side effects of Galafold?

The most common side effects of Galafold include headache, stuffy or runny nose and sore throat, urinary tract infection, nausea, and fever.

These are not all the possible side effects of Galafold. Call your healthcare provider for medical advice about side effects.

You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Amicus Therapeutics at 1-877-4AMICUS.

What is Galafold?

Galafold is a prescription medicine used to treat adults with Fabry disease who have a certain genetic change (variant) in the galactosidase alpha gene (GLA) that is responsive (amenable) to Galafold.

It is not known if Galafold is safe and effective in children.

Please click here for Full Prescribing Information, including Patient Information and Instructions for Use.

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